Xylometazoline Hydrochloride

Indications
 Nasal
Nasal congestion
Adult: As 0.1% solution: Instill into each nostril bid-tid. Max duration: 7 days.
Child: As 0.05% solution: 3 mth-12 yr: 1-2 drops into each nostril once or bid. Max duration: 7 days.
Ophthalmic
Conjunctival decongestant
Adult: As 0.05-0.1% solution: Instil into the eye.
Contraindications
 Angle closure glaucoma; dry rhinitis; post trans-sphenoidal hypophysectomy, trans-nasal, trans-oral surgery where dura mater is exposed.
Warnings / Precautions
 Young children, pregnancy and lactation. Hypertension, CV abnormalities, DM, hyperthyroidism, history of excessive reaction to sympathomimetics, difficulty in urination secondary to prostate enlargement. Rebound congestion may occur after prolonged regular use.
Adverse Reactions
 Headache, insomnia, tachycardia, hypertension, nervousness, nausea, dizziness, palpitation, arrhythmia. Nasal drops: Local stinging or burning, sneezing, dryness of mouth and throat, nausea. Eye drops: Dryness of eye.
Drug Interactions
 Increased heart rate or BP with sibutramine.
Potentially Fatal: Hypertensive crisis with MAOIs.
See Below for More xylometazoline hydrochloride Drug Interactions
Mechanism of Actions
 Xylometazoline is a direct-acting sympathomimetic which has a vasoconstrictor effect by reducing swelling and congestion when applied to mucous membranes.
Onset: 5-10 min.
Duration: 10 hr.
Storage Conditions
 Nasal: Store below 30°C. Ophthalmic: Store below 30°C.
ATC Classification
 R01AA07 - xylometazoline ; Belongs to the class of topical sympathomimetic agents used as nasal decongestants.
R01AB06 - xylometazoline ; Belongs to the class of topical sympathomimetic combination preparations, excluding corticosteroids. Used as nasal decongestants.
S01GA03 - xylometazoline ; Belongs to the class of sympathomimetics used as ophthalmologic decongestants.
Storage
 Nasal: Store below 30°C. Ophthalmic: Store below 30°C.
Available As
  • Xylometazoline Hydrochloride 0..05% w/w
  • Xylometazoline Hydrochloride 0.01% w/v
  • Xylometazoline Hydrochloride 0.025% w/v
  • Xylometazoline Hydrochloride 0.05 % w/v
  • Xylometazoline Hydrochloride 0.05%
  • Xylometazoline Hydrochloride 0.05% w/v
  • Xylometazoline Hydrochloride 0.1%
  • Xylometazoline Hydrochloride 0.1% w/v
  • Xylometazoline Hydrochloride 0.1% w/w
  • Xylometazoline Hydrochloride 0.1%w/v
  • Xylometazoline Hydrochloride 0.25 mg
  • Xylometazoline Hydrochloride 0.5 mg
  • Xylometazoline Hydrochloride 0.65% w/v
  • Xylometazoline Hydrochloride 1%
  • Xylometazoline Hydrochloride 1.4%

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