Vit E

Indications
 Oral
Vitamin E deficiency
Adult: 40-50 mg of d-α tocopherol daily.
Child: Neonate: 10 mg/kg once daily; 1 mth-18 yr: 2-10 mg/kg/day, up to 20 mg/kg.
Oral
Supplementation in cystic fibrosis
Adult: 100-200 mg daily of dl-α-tocoferil acetate or 67-135 mg daily of d-α-tocopherol.
Child: As α- tocopheryl acetate: 1 mth-1 yr 50 mg once daily; 1-12 yr 100 mg once daily; 12-18 yr 200 mg once daily. Dose to be adjusted as needed.
Oral
Abetalipoproteinaemia
Adult: 50-100 mg/kg daily of dl-α-tocoferil acetate or about 33-67 mg/kg daily of d-α-tocopherol.
Child: Neonate: 100 mg/kg once daily; 1 mth-18 yr: 50-100 mg/kg once daily.
Adverse Reactions
 Hypertension; myopathy; thrombophloebitis; fatigue, weakness, nausea, headache, dizziness, blurred vision, flatulence, diarrhoea, abdominal pain. Topical: Contact dermatitis.
Drug Interactions
 Colestyramine, colestipol, and orlistat may interfere with vitamin E absorption. High doses of vitamin E potentiates the anticoagulant action of warfarin. Large doses of vitamin E may impair response to iron supplementation.
See Below for More vitamin e Drug Interactions
Mechanism of Actions
 Vitamin E is a general term used to refer to a large number of natural or synthetic compounds. Tocopherols are the most common compounds, of which alpha tocopherols are the most active and widely distributed in nature. Alpha tocopherols occur naturally in the d optical isomer form and is more active than the synthetic racemic dl form. d-α-tocopheryl acetate is the acetate ester of natural source d-α-tocopherol. Other naturally occurring tocopherols e.g. beta, gamma, and delta tocopherols are not used clinically. Tocotrienols are another group of compounds with vitamin E activity. Vitamin E, a fat soluble vitamin, reacts with free radicals and protects RBCs against haemolysis and polysaturated fatty acids in membranes against free radical attack.
Absorption: 20-80% (oral). Absorption depends on the presence of bile and on normal pancreatic function; decrease with increasing dose.
Distribution: Enters blood via the chylomicrons in the lymph; bound to β-lipoproteins. Widely distributed to all tissues. Stored in adipose tissue. Enters breast milk but crosses the placenta poorly.
Metabolism: Hepatic; converted to glucuronides of tocopheronic acid and its γ-lactone.
Excretion: Excreted mainly via bile into faeces and some into urine.
Administration
 Should be taken with food.
Available As
  • Vit E 0.05%
  • Vit E 0.05% w/w
  • Vit E 0.1%
  • Vit E 0.18% w/w
  • Vit E 0.2% w/w
  • Vit E 0.25%
  • Vit E 0.25% w/w
  • Vit E 0.4 mg
  • Vit E 0.5 iu
  • Vit E 0.5 mg
  • Vit E 0.5%
  • Vit E 0.5% w/w
  • Vit E 0.50%
  • Vit E 1 iu
  • Vit E 1 mg
  • Vit E 1%
  • Vit E 1% w/w
  • Vit E 1.5 iu
  • Vit E 1.5 mg
  • Vit E 1.75 iu
  • Vit E 10 i.u
  • Vit E 10 i.u.
  • Vit E 10 iu
  • Vit E 10 mcg
  • Vit E 10 mg
  • Vit E 10%
  • Vit E 10.4 mg
  • Vit E 10.80 iu
  • Vit E 100 iu
  • Vit E 100 mg
  • Vit E 11 iu
  • Vit E 11 mg
  • Vit E 11.1 mg
  • Vit E 11.3 iu
  • Vit E 11.4 iu
  • Vit E 11.5 iu
  • Vit E 11.5 mg
  • Vit E 11.6 iu
  • Vit E 12 iu
  • Vit E 12 mg
  • Vit E 12.31 iu
  • Vit E 12.32 iu
  • Vit E 12.5 iu
  • Vit E 12.5 mg
  • Vit E 13.4 mg
  • Vit E 134 mg
  • Vit E 14 mg
  • Vit E 14.6 iu
  • Vit E 15 iu
  • Vit E 15 mg
  • Vit E 15 units
  • Vit E 150 iu
  • Vit E 150 mg
  • Vit E 16 iu
  • Vit E 16 mg
  • Vit E 16.67 mg
  • Vit E 16.7 mg
  • Vit E 16.75 mg
  • Vit E 17 mg
  • Vit E 18 mg
  • Vit E 19.46 mg
  • Vit E 2 iu
  • Vit E 2 mg
  • Vit E 2.05%
  • Vit E 2.05% w/w
  • Vit E 2.5 iu
  • Vit E 2.5 mg
  • Vit E 2.50 iu
  • Vit E 2.50 mg
  • Vit E 2.55 mg
  • Vit E 20 iu
  • Vit E 20 mg
  • Vit E 200 iu
  • Vit E 200 mcg
  • Vit E 200 mg
  • Vit E 25 i.u
  • Vit E 25 i.u.
  • Vit E 25 iu
  • Vit E 25 mcg
  • Vit E 25 mg
  • Vit E 25.5 iu
  • Vit E 251 iu
  • Vit E 26 mg
  • Vit E 268 mg
  • Vit E 28.3 iu
  • Vit E 3 iu
  • Vit E 3 mg
  • Vit E 3.3% w/w
  • Vit E 3.32 mcg
  • Vit E 3.5 iu
  • Vit E 30 iu
  • Vit E 30 mcg
  • Vit E 30 mg
  • Vit E 300 iu
  • Vit E 300 mg
  • Vit E 4 iu
  • Vit E 4 mg
  • Vit E 4.6 mg
  • Vit E 4.7 mg
  • Vit E 4.95 mcg
  • Vit E 40 iu
  • Vit E 40 mg
  • Vit E 400 iu
  • Vit E 400 mg
  • Vit E 45 mcg
  • Vit E 46.66 iu
  • Vit E 48 mg
  • Vit E 5 iu
  • Vit E 5 mcg
  • Vit E 5 mg
  • Vit E 5%
  • Vit E 5.0 iu
  • Vit E 5.3 mg
  • Vit E 5.7 iu
  • Vit E 5.9 mg
  • Vit E 50 i.u
  • Vit E 50 iu
  • Vit E 50 mg
  • Vit E 500 mg
  • Vit E 5000 mcg
  • Vit E 6 iu
  • Vit E 6 mg
  • Vit E 6.7 mg
  • Vit E 6.8 mg
  • Vit E 600 mg
  • Vit E 66.5 mg
  • Vit E 67 mg
  • Vit E 7 iu
  • Vit E 7 mg
  • Vit E 7.2 iu
  • Vit E 7.25 iu
  • Vit E 7.5 iu
  • Vit E 7.5 mg
  • Vit E 7.7 mg
  • Vit E 7.8 mg
  • Vit E 8 iu
  • Vit E 8 mg
  • Vit E 9.6 mg
  • Vit E 9.73 mg

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