Travoprost

Indications
 Ophthalmic
Ocular hypertension, Open-angle glaucoma
Adult: 1 drop of 0.004% soln in the affected eye(s) once every evening.
Renal impairment: Use with caution.
Hepatic impairment: Use with caution.
Contraindications
 Active intraocular inflammation. Pregnancy.
Warnings / Precautions
 Aphakia or pseudophakia with torn posterior lens capsule; risk factors for cystoid macular oedema; history of intraocular inflammation; hepatic or renal impairment. Monitor for iris colour change. Contact lens to be removed before use and re-inserted 15 min after application. Lactation.
Adverse Reactions
 Increase in brown pigmentation of iris and periorbital tissue; ocular hyperaemia; decreased visual acuity; foreign body sensation; blepharitis; ocular irritation and pain; darkening, thickening and lengthening of eyelashes; macular oedema.
Mechanism of Actions
 Travoprost, a prodrug and synthetic analogue of dinoprost (prostaglandin F2α), reduces intraocular pressure by increasing uveoscleral outflow of aqueous humour.
Onset: 2 hr.
Duration: At least 24 hr.
Absorption: Absorbed through cornea after ocular instillation. Peak plasma concentration of travoprost free acid in 30 min.
Metabolism: Hydrolysed by esterases in the cornea to its biologically active free acid. Metabolised to inactive metabolites systemically. Mean terminal elimination half-life of travoprost free acid: 45 min.
Excretion: Excreted in urine (<2% as active metabolite).
Storage Conditions
 Ophthalmic: Store at 2-25°C (36-77°F).
ATC Classification
 S01EE04 - travoprost ; Belongs to the class of prostaglandin analogues. Used in the treatment of glaucoma.
Storage
 Ophthalmic: Store at 2-25°C (36-77°F).
Available As
  • Travoprost 0.004%
  • Travoprost 0.004% w/v
  • Travoprost 40 mcg
  • Travoprost 40 mg

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