Terbinafine

Indications
 Oral
Dermatophytosis
Adult: 250 mg once daily for 2-4 wk in tinea cruris, 6 wk for tinea pedis, 4 wk for tinea corporis and 6-12 wk for nail infections.
Child: 10-20 kg: 62.5 mg; 20-40 kg: 125 mg; >40 kg: 250 mg. Doses to be taken once daily. Treatment is usually given for 2 wk for tinea capitis; 2-4 wk for tinea cruris; 4 wk for tinea corporis; 6 wk in tinea pedis; 6-12 wk for nail infections.
CrCl (ml/min)Dosage Recommendation
<50Half the usual oral dose.

Topical/Cutaneous
Dermatophytosis
Adult: Apply a 1% cream/solution once or bid. 1-2 wk to treat tinea corporis and tinea cruris; 1-wk course is for tinea pedis; 2-wk course in cutaneous candidiasis and pityriasis versicolor
Contraindications
 Hypersensitivity, active or chronic liver disease, lactation.
Warnings / Precautions
 Preexisting liver or renal impairment, pregnancy. Perform liver function tests prior to oral therapy.
Adverse Reactions
 Anorexia, nausea, abdominal pain, taste disturbances, diarrhoea, rash, urticaria.
Potentially Fatal: Liver failure, Stevens-Johnson syndrome, neutropaenia.
Drug Interactions
 Possible increase in levels in drugs metabolised by CYP450 2D6. Decreased terbinafine concentration with rifampicin; increased terbinafine concentration with cimetidine.
See Below for More terbinafine Drug Interactions
Food Interactions
 Oral bioavailability increased when administered with food.
Mechanism of Actions
 Terbinafine causes fungal cell death by inhibiting squalene epoxidase, the main enzyme in sterol biosynthesis, resulting in ergosterol deficiency within fungal cell walls. It has fungicidal activity against dermatophytes and some yeast.
Absorption: Absorbed well from the GI tract with 40% bioavailability (oral), minimal absorption (topical); peak plasma concentrations after 2 hr (oral).
Distribution: Distributed into stratum corneum of the skin, nail plate, hair (concentrations higher than plasma) and breastmilk. Protein-binding: Extensive.
Metabolism: Hepatic; converted to inactive metabolites.
Excretion: Via urine; 17-36 hr (plasma elimination half-life); up to 400 hr (terminal elimination half-life) in prolonged therapy.
Administration
 May be taken with or without food.
Storage Conditions
 Oral: Tab: Store below 25°C. Protect from light.
ATC Classification
 D01AE15 - terbinafine ; Belongs to the class of other antifungals for topical use.
D01BA02 - terbinafine ; Belongs to the class of antifungals for systemic use.
Storage
 Oral: Tab: Store below 25°C. Protect from light.
Available As
  • Terbinafine 1%
  • Terbinafine 1% w/v
  • Terbinafine 1% w/w
  • Terbinafine 10 mg
  • Terbinafine 125 mg
  • Terbinafine 250 mg

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    One Response to Terbinafine

    1. April 30, 2014 at 12:29 pm #

      in this cream, Terbinafine is how much equivalent to Terbinafine HCl..??? …plz give me this information

      Reply

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