Sulphacetamide Sodium

Indications
 Ophthalmic
Ocular infections
Adult: As sodium: Apply 10-30% eye drops or 10% ointment into the affected eye/s. May be used up to tid.
Contraindications
 Hypersensitivity; infants <2 mth.
Warnings / Precautions
 Elderly. History of allergy or asthma; G6PD deficiency; renal and hepatic impairment. Prolonged therapy requires CBC and urinalysis with microscopic examination. Maintain adequate fluid intake. Pregnancy, lactation.
Adverse Reactions
 Hypersensitivity skin reaction. Ophthalmic: Burning, stinging, conjunctivitis, corneal ulcers, irritation, conjunctival hyperaemia. Systemic absorption from inflamed conjunctiva.
Potentially Fatal: Stevens-Johnson syndrome.
Drug Interactions
 Action antagonised by PABA and procaine group of local anaesthetics. PABA present in purulent eye exudates can competitively inhibit the action of sulphacetamide.
See Below for More sulfacetamide Drug Interactions
Lab Interactions
 May interfere with diagnostic tests e.g. urinary glucose, urobilinogen, urea and creatinine.
Mechanism of Actions
 Sulfacetamide has bacteriostatic effect on a wide range of gram-positive and gram-negative organisms. It interferes with nucleic acid synthesis thus blocking conversion of PABA to the coenzyme dihydrofolic acid.
Absorption: Penetrates into ocular tissues and fluids (ophthalmic).
Excretion: Urine (as unchanged drug); 7-13 hr (elimination half-life).
Storage Conditions
 Ophthalmic: Store below 25°C.
ATC Classification
 S01AB04 - sulfacetamide ; Belongs to the class of antiinfectives, sulfonamides. Used in the treatment of eye infections.
Storage
 Ophthalmic: Store below 25°C.
Available As
  • Sulphacetamide Sodium 10%
  • Sulphacetamide Sodium 10% w/v
  • Sulphacetamide Sodium 10% w/w
  • Sulphacetamide Sodium 12% w/v
  • Sulphacetamide Sodium 12.5%
  • Sulphacetamide Sodium 12.5% w/v
  • Sulphacetamide Sodium 15%
  • Sulphacetamide Sodium 15% w/v
  • Sulphacetamide Sodium 2.5% w/w
  • Sulphacetamide Sodium 2.86%
  • Sulphacetamide Sodium 2.86% w/w
  • Sulphacetamide Sodium 20%
  • Sulphacetamide Sodium 20% w/v
  • Sulphacetamide Sodium 30 mg
  • Sulphacetamide Sodium 30%
  • Sulphacetamide Sodium 30% w/v
  • Sulphacetamide Sodium 60 mg

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