Permethrin

Indications
 Topical/Cutaneous
Head pediculosis
Adult: Apply 30-60 ml of 1% lotion (cream rinse) to washed and towel-dried hair and allow to remain for 10 min. Rinse with water. Treatment may be repeated after 7-10 days if lice or nits are detected in hair-scalp junctions.
Topical/Cutaneous
Scabies
Adult: Apply a thin layer of 5% cream into all skin surfaces from the neck to toes. Wash off after 8-14 hr. 30 g of cream is usually sufficient for an average adult.
Topical/Cutaneous
Pediculosis pubis
Adult: Apply sufficient amount of 1% lotion (cream rinse) or 5% cream to thoroughly saturate the pubic area. Allow to remain for 10 min and then rinse with water.
Contraindications
 Hypersensitivity.
Warnings / Precautions
 Avoid contact with eyes and mucous membranes. Cross-sensitivity may occur with ragweed or chrysanthemums. History of asthma. Pregnancy and lactation.
Adverse Reactions
 Mild and transient burning, stinging, pruritus, erythema, tingling, numbness, rash; difficulty in breathing; phototoxic or photosensitisation reactions.
Mechanism of Actions
 Permethrin is a pyrethroid pediculocide and scabicide. It causes paralysis and death of the pest by inhibiting sodium ion influx through nerve cell membrane channels delaying repolarisation.
Absorption: Small amounts absorbed systemically (topical).
Metabolism: Hepatic via ester hydrolysis; converted to inactive metabolites.
Excretion: Via urine
Storage Conditions
 Topical/Cutaneous: Cream: Store at 15-25°C (59-77°F). Lotion (Cream rinse): Store at 15-25°C (59-77°F) or at 20-25°C (68-77°F).
ATC Classification
 P03AC04 - permethrin ; Belongs to the class of pyrethrines, including synthetic compounds used as ectoparasiticides.
Storage
 Topical/Cutaneous: Cream: Store at 15-25°C (59-77°F). Lotion (Cream rinse): Store at 15-25°C (59-77°F) or at 20-25°C (68-77°F).
Available As
  • Permethrin 1%
  • Permethrin 1% w/v
  • Permethrin 1% w/w
  • Permethrin 10 mg
  • Permethrin 2%
  • Permethrin 30 gm
  • Permethrin 5%
  • Permethrin 5% w/v
  • Permethrin 5% w/w
  • Permethrin 50 mg

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