Neomycin

Indications
 Oral
Preoperative intestinal antisepsis
Adult: 1 g every hr for 4 doses then every 4 hr for 2-3 days; or 1 g at 1 PM, 2 PM and 11 PM on the day before surgery as an adjunct to mechanical cleansing of the intestine and in combination with oral erythromycin; or 6 g/day divided every 4 hr for 2-3 days.
Child: 90 mg/kg/day divided every 4 hr for 2 days; or 25 mg/kg at 1 PM, 2 PM and 11 PM on the day before surgery as an adjunct to mechanical cleansing of the intestine and in combination with erythromycin base.
Renal impairment: Dose modification required.
Oral
Adjunct in hepatic encephalopathy
Adult: 4-12 g daily in divided doses for 5-7 days.
Child: 50-100 mg/kg/day in divided doses every 6-8 hr or 2.5-7 g/m2/day divided every 4-6 hr for 5-6 days. Max: 12 g/day.
Renal impairment: Dose modification required.
Oral
Chronic hepatic insufficiency
Adult: 4 g/day for an indefinite period.
Renal impairment: Dose modification required.
Otic/Aural
Otic infections
Adult: Per ml solution contains neomycin sulfate 3.5 mg, polymyxin B sulfate 10,000 units and hydrocortisone acetate 10 mg: Instill 4 drops into the affected ear(s) 3 or 4 times daily. Treatment duration should be limited to 10 consecutive days.
Ophthalmic
Susceptible ophthalmic infections
Adult: Per ml solution contains neomycin sulfate 3.5 mg, polymyxin B sulfate 10,000 units and dexamethasone 1 mg: Instill 1-2 drops into the affected eye(s) 4-6 times daily, up to hrly admin in severe cases.
Topical/Cutaneous
Skin infections
Adult: Per g cream contains neomycin sulfate 3.5 mg, polymyxin B sulfate 10,000 units and hydrocortisone acetate 5 mg: Apply onto affected area 2-4 times daily as needed. May gently rub cream into affected areas if conditions permit.
Child: In combination with anti-infectives: Apply ointment or cream to affected area 1-3 times/day. In combination with corticosteroids and other anti-infectives: Apply ointment or cream to affected area 2-4 times/day. As irrigation: Topical solutions of 0.1-1% have been used.
Contraindications
 Do not use for intestinal disinfection if there is intestinal obstruction. Hypersensitivity to aminoglycosides. Infants <1 yr. Inflammatory or ulcerative GI disease (oral). Pregnancy. Not to be used topically or for urological purposes in doses >1 g daily or urologically for >10 days. Extensive skin damage or perforation of the eardrum (otic application). Do not admin parenterally or as peritoneal lavage.
Warnings / Precautions
 Kidney or liver disease; neuromuscular disorders (e.g. myasthenia gravis, parkinsonism); impaired hearing (pre-existing vertigo, tinnitus, hearing loss). Monitor auditory and renal function in patients with additional risk factors. Monitor patients on high doses or prolonged courses. Elderly, dehydrated patients. Avoid prolonged use. Lactation.
Adverse Reactions
 Oral: Nausea, diarrhoea, vomiting, irritation or soreness of the mouth or rectal area; dyspnoea, eosinophilia, nephrotoxicity, neurotoxicity, ototoxicity (auditory and vestibular). Topical: Contact dermatitis.
Potentially Fatal: Neuromuscular blockade and respiratory paralysis.
Overdose Reactions
 Rare due to poor oral absorption. Symptoms: Ototoxicity, nephrotoxicity, neuromuscular toxicity. Treatment: Single acute overdose: Maintain urine output of at least 3 ml/kg/hr during the acute treatment phase. Haemodialysis is preferred over peritoneal dialysis in patients with normal renal function. Chelation with penicillin may be useful.
Drug Interactions
 Synergistic effects with penicillins. Additive toxicity with neurotoxic, ototoxic or nephrotoxic drugs. May decrease absorption of digoxin and methotrexate. May increase effects of oral anticoagulants.
See Below for More neomycin Drug Interactions
Mechanism of Actions
 Neomycin is an aminoglycoside antibiotic. It binds to 30S ribosomal subunits of bacterial ribosome thus inhibiting protein synthesis and generating errors in genetic code transcription causing cell death. It acts against many gram-negative aerobes and some gram-positive aerobes. It lacks activity against fungi, viruses and most anaerobic bacteria.
Absorption: Poorly absorbed from the GI tract; increased in the presence of damaged or inflamed mucosa. Absorption may occur from the peritoneum, respiratory tract, bladder, wounds, and inflamed skin.
Distribution: Low levels in intestinal wall and muscles.
Excretion: Via faeces (about 97% of an oral dose unchanged); via urine (active form). Half-life: 2-3 hr; 12-24 hr in adults with severe renal impairment.
Administration
 May be taken with or without food.
Storage Conditions
 Ophthalmic: Store at 15-30°C (59-86°F). Oral: Store at 20-25°C (68-77°F). Otic/Aural: Store at 15-30°C (59-86°F). Topical/Cutaneous: Store at 15-30°C (59-86°F).
ATC Classification
 A01AB08 - neomycin ; Belongs to the class of local antiinfective and antiseptic preparations. Used in the treatment of diseases of the mouth.
D06AX04 - neomycin ; Belongs to the class of other topical antibiotics used in the treatment of dermatological diseases.
J01GB05 - neomycin ; Belongs to the class of other aminoglycosides. Used in the systemic treatment of infections.
A07AA01 - neomycin ; Belongs to the class of antibiotics. Used in the treatment of intestinal infections.
R02AB01 - neomycin ; Belongs to the class of antibiotics used in throat preparations.
S01AA03 - neomycin ; Belongs to the class of antibiotics. Used in the treatment of eye infections.
S02AA07 - neomycin ; Belongs to the class of antiinfectives used in the treatment of ear infections.
S03AA01 - neomycin ; Belongs to the class of antiinfectives used in ophthalmologic and otologic preparations.
B05CA09 - neomycin ; Belongs to the class of antiinfectives used as irrigating solutions.
Storage
 Ophthalmic: Store at 15-30°C (59-86°F). Oral: Store at 20-25°C (68-77°F). Otic/Aural: Store at 15-30°C (59-86°F). Topical/Cutaneous: Store at 15-30°C (59-86°F).
Available As
  • Neomycin 0.05%
  • Neomycin 0.05% w/w
  • Neomycin 0.1%
  • Neomycin 0.1% w/w
  • Neomycin 0.2%
  • Neomycin 0.25%
  • Neomycin 0.25% w/w
  • Neomycin 0.3% w/v
  • Neomycin 0.35%
  • Neomycin 0.35% w/v
  • Neomycin 0.35% w/w
  • Neomycin 0.5%
  • Neomycin 0.5% w/v
  • Neomycin 0.5% w/w
  • Neomycin 0.50% w/v
  • Neomycin 0.50% w/w
  • Neomycin 0.500% w/w
  • Neomycin 0.55%
  • Neomycin 0.57%
  • Neomycin 1% w/v
  • Neomycin 1% w/w
  • Neomycin 100 mg
  • Neomycin 1700 iu
  • Neomycin 2.5 mg
  • Neomycin 20 mg
  • Neomycin 3.5 mg
  • Neomycin 330 units
  • Neomycin 3300 units
  • Neomycin 3400 iu
  • Neomycin 3400 units
  • Neomycin 350 mg
  • Neomycin 5 mg
  • Neomycin 5%
  • Neomycin 5% w/w
  • Neomycin 500 mg

    • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Neomycin


    Neomycin Containing Brands

    We are Developing Our database, More results coming soon.

    Neomycin is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Neomycin

    We are Developing Our database, More results coming soon.