Naphazoline

Indications
 Nasal
Nasal congestion
Adult: 1-2 drops or spray of 0.05-0.1% solution every 6 hr.
Child: ≥12 yr: 1-2 drops or spray of 0.05% solution every 6 hr. Therapy should not exceed 3 days.
Ophthalmic
Conjunctival decongestant
Adult: 1-2 drops of 0.1% solution to the conjunctiva every 3-4 hr as needed. Alternatively, 1-2 drops of a 0.01-0.03% solution to the conjunctiva up to 4 times daily.
Contraindications
 Narrow-angle glaucoma.
Warnings / Precautions
 Pregnancy and lactation. Not recommended in infants and young children. Chronic asthma, hypertension, heart failure, coronary artery disease, cerebral arteriosclerosis, DM, hyperthyroidism, local infection or injury, benign prostatic hyperplasia. Rebound hyperaemia may occur on prolonged use (ophthalmic).
Adverse Reactions
 Cardiac abnormalities, hypertension; reduced body temperature, dizziness, drowsiness, headache, nervousness; hyperglycaemia; nausea; transient stinging, nasal mucosa irritation, dryness, rebound congestion; weakness; blurred vision, discomfort, increased intraocular pressure, irritation, lacrimation, mydriasis, punctuate keratitis, redness; sneezing; diaphoresis.
Overdose Reactions
 Symptoms: CNS depression, hypothermia, bradycardia, CV collapse, apnoea, coma, agitation, tachycardia, hypertension; alternating agitation and hypertension. Management: Symptom-directed and supportive.
Drug Interactions
 Pressor effects may be potentiated by TCAs. Mydriatic effects may be increased by methyldopa, guanadrel.
Potentially Fatal: Hypertensive crisis may occur when used with MAOIs.
See Below for More naphazoline Drug Interactions
Mechanism of Actions
 Naphazoline, an imidazoline derivative sympathomimetic amine, produces vasoconstriction by stimulating the α-adrenergic receptors in the arterioles of the conjunctiva and the nasal mucosa.
Onset: Decongestant: Topical: Approx 10 min.
Duration: 2-6 hr.
Absorption: Not given systemically, but readily absorbed from the GI tract.
Storage Conditions
 Nasal: Store at controlled room temperature. Ophthalmic: Store at controlled room temperature.
ATC Classification
 R01AA08 - naphazoline ; Belongs to the class of topical sympathomimetic agents used as nasal decongestants.
R01AB02 - naphazoline ; Belongs to the class of topical sympathomimetic combination preparations, excluding corticosteroids. Used as nasal decongestants.
S01GA01 - naphazoline ; Belongs to the class of sympathomimetics used as ophthalmologic decongestants.
Storage
 Nasal: Store at controlled room temperature. Ophthalmic: Store at controlled room temperature.
Available As
  • Naphazoline 0.01% w/v
  • Naphazoline 0.02% w/v
  • Naphazoline 0.025%
  • Naphazoline 0.036%
  • Naphazoline 0.05%
  • Naphazoline 0.05% w/v
  • Naphazoline 0.056%
  • Naphazoline 0.056% w/v
  • Naphazoline 0.1%
  • Naphazoline 0.1% w/v
  • Naphazoline 0.56 mg
  • Naphazoline 0.56% w/v

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