Indications |
Oral Iron-deficiency anaemia Adult: Usual dose range: Up to 600 mg daily. May increase up to 1.2 g daily if necessary. Child: As syrup containing 140 mg(45 mg iron)/5ml. Preterm neonate: 0.6-2.4 ml/kg daily; up to 6 yr: 2.5-5 ml bid. |
Warnings / Precautions |
Patients with intestinal strictures and diverticular disease. May worsen diarrhoea in patients with inflammatory bowel disease. May cause constipation and faecal impaction in elderly. Avoid prolonged admin (>6 mth) except in patients with continued bleeding, menorrhagia or repeated pregnancies. Not for routine use in treatment of haemolytic anaemia unless an iron-deficient state exists. Parenteral iron should not be used concurrently with oral iron treatment. Avoid use in patients receiving repeated blood tranfusions. Pregnancy. |
Adverse Reactions |
GI disturbance including constipation, diarrhoea, dark stools. Nausea and epi-gastric pain. |
Overdose Reactions |
Symptoms: Nausea, vomiting, abdominal pain, diarrhoea, haematemesis and rectal bleeding. Hypotension, coma and hepatocellular necrosis may occur later. Treatment: Empty stomach contents by gastric lavage within 1 hr of ingestion. In severe toxicity, IV desferrioxamine may be given. Whole bowel irrigation may also be considered in severe poisoning. |
Drug Interactions |
Oral absorption of iron may be increased when taken with ascorbic acid. May reduce the absorption of quinolones and tetracyclines when taken concurrently via the oral route. Concurrent admin with antacids may reduce the absorption of ferrous fumarate from the GI tract. May reduce the absorption of penicillamine in the gut when taken concurrently. See Below for More ferrous fumarate Drug Interactions |
Mechanism of Actions |
Ferrous fumarate is an iron preparation that is used in the prevention and treatment of iron deficiency. The amount of elemental iron is 330 mg/g of ferrous fumarate. Absorption: GI iron absorption depends on the amount of stored iron in the body; absorption is higher when stored iron is low. Distribution: Ferrous iron passes through the GI mucosal cells, bind to transferrin and is then transported to the bone marrow and incorporated into haemoglobin. Excretion: Mainly through the faeces and desquamation of cells e.g. skin, hair or GI mucosa. |
Administration |
Should be taken on an empty stomach. (Best taken on an empty stomach. May be taken w/ meals to reduce GI discomfort.) |
ATC Classification |
B03AA02 - ferrous fumarate ; Belongs to the class of oral iron bivalent preparations. Used in the treatment of anemia. B03AD02 - ferrous fumarate ; Belongs to the class of iron in combination with folic acid. Used in the treatment of anemia. |
Available As |
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Ferrous Fumarate
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Ferrous Fumarate Containing Brands
Ferrous Fumarate is used in following diseases
Drug - Drug Interactions of Ferrous Fumarate
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