Dorzolamide

Indications
Ophthalmic
Ocular hypertension, Open-angle glaucoma
Adult: As 2% eye drops: 1 drop tid; bid when used with a topical β-blocker.
Contraindications
Severe renal impairment; hypersensitivity; hyperchloraemic acidosis. Lactation.
Warnings / Precautions
Hepatic impairment; systemic absorption following topical admin; history of renal calculi or intraocular surgery; chronic corneal defects; risk of choroidal detachment when used after filtration procedures.
Adverse Reactions
Conjunctivitis; superficial punctate keratitis; ocular burning, stinging or itching; eyelid inflammation and crusting; blurred vision; lachrymation; anterior uveitis; transient myopia; corneal oedema; iridocyclitis; headache; dizziness; paraesthesia; asthenia; sinusitis; nausea; hypersensitivity reactions; bitter taste; epistaxis; urolithiasis; rhinitis.
Drug Interactions
Enhance effects of amphetamines, ephedrine, quinidine. Reduce effects of methenamine and its compounds. Enhance antiepileptic-induced osteomalacia. Severe acidosis and increased CNS toxicity with aspirin. Increased excretion of lithium.
See Below for More dorzolamide Drug Interactions
Mechanism of Actions
Dorzolamide is a carbonic anhydrase inhibitor that reduces formation of hydrogen and carbonate ions from CO2 and water thereby reducing aqueous humor secretion, thus lowering intraocular pressure.
Storage Conditions
Ophthalmic: Store at 15-30°C.
ATC Classification
S01EC03 - dorzolamide ; Belongs to the class of carbonic anhydrase inhibitors. Used in the treatment of glaucoma.
Storage
Ophthalmic: Store at 15-30°C.
Available As
  • Dorzolamide 2%
  • Dorzolamide 2% w/v
  • Dorzolamide 20 mg
  • Dorzolamide 22.26 mg
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