Domperidone

Indications
 Oral
Nausea and vomiting
Adult: 10-20 mg every 4-8 hr. Max: 80 mg/day.
Child: >2 yr and >35 kg: 10-20 mg 3-4 times daily. Max: 80 mg daily.
Oral
Non ulcer dyspepsia
Adult: 10-20 mg tid and at night.
Oral
Migraine
Adult: 20 mg every 4 hr, in combination with paracetamol, as required. Max: 4 doses in 24 hr.
Rectal
Nausea and vomiting
Adult: 60 mg bid.
Child: 60 mg bid.
Max Dosage:

Special Populations: Use in childn is restricted to nausea and vomiting following cytotoxics or radiotherapy:
Contraindications
 Hypersensitivity. GI haemorrhage, obstruction and perforation, patients with prolactin releasing pituitary hormone, chronic admin or routine prophylaxis of postoperative nausea and vomiting.
Warnings / Precautions
 Phaeochromocytoma; children<2 yr, elderly; renal or hepatic impairment. Risk of cardiac arrhythmias and hypokalaemia if administered IV. Pregnancy and lactation.
Adverse Reactions
 Drowsiness, extrapyramidal reactions, galactorrhoea, gynaecomastia; constipation or diarrhoea, lassitude, decreased libido, skin rash, itch.
Potentially Fatal: Convulsions, arrhythmias and cardiac arrest, dysrrhythmias in patients with CV disease or hypokalaemia, patients on cancer chemotherapy. Seizures; hypertensive crisis in patients with phaeochromocytoma.
Drug Interactions
 Reduces absorption of digoxin. Increases absorption of aspirin, paracetamol and oral diazepam. Enhances CNS depression by phenothiazine. Antimuscarinic agents and opioids antagonise GI effects. May antagonise hypoprolactinaemic effect of drugs such as bromocriptine. Increased effects when used with CYP3A4 inhibitors such as erythromycin or ritonavir.
See Below for More domperidone Drug Interactions
Food Interactions
 Delayed absorption but higher bioavailability due to reduced first-pass metabolism in gut wall.
Mechanism of Actions
 Domperidone is a peripheral dopamine-receptor blocker. It increases oesophageal peristalsis, lower oesophageal sphincter pressure, gastric motility and peristalsis, thus facilitating gastric emptying and decreasing small bowel transit time.
Onset: Oral: 30 min-1hr.
Duration: Oral: 6-8 hr.
Absorption: Peak plasma concentrations after 1 hr (rectal), 30 min (oral).
Distribution: Enters breast milk (small amounts). Protein-binding: >90%.
Metabolism: Extensively hepatic.
Excretion: Urine (as metabolites), faeces (as unchanged drug); 7.5 hr (elimination half-life).
Administration
 Should be taken on an empty stomach. (Take 15-30 min before meals.)
Storage Conditions
 Oral: Store at 15-30°C. Rectal: Store at 15-30°C.
ATC Classification
 A03FA03 - domperidone ; Belongs to the class of propulsives. Used in the treatment of functional gastrointestinal disorders.
Storage
 Oral: Store at 15-30°C. Rectal: Store at 15-30°C.
Available As
  • Domperidone 1 mg
  • Domperidone (IR) 10 mg
  • Domperidone 10 mg
  • Domperidone (SR) 10 mg
  • Domperidone Maleate 10 mg
  • Domperidone 15 mg
  • Domperidone Maleate 15 mg
  • Domperidone 2 mg
  • Domperidone (SR) 20 mg
  • Domperidone 20 mg
  • Domperidone (SR) 30 mg
  • Domperidone 30 mg
  • Domperidone (IR) 30 mg
  • Domperidone (SR) 30 ml
  • Domperidone 40 mg
  • Domperidone 5 mg
  • Domperidone 50 mg

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    One Response to Domperidone

    1. October 26, 2014 at 11:54 am #

      Very useful site

      Reply

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