Dextromethorphan

Indications
 Oral
Cough suppressant
Adult: 10-20 mg every 4 hr, or 30 mg every 6-8 hr. Extended-release oral suspension: 60 mg bid. Max: 120 mg/day.
Child: 6-12 yr: 5-10 mg every 4 hr or 15 mg every 6-8 hr; 2-6 yr: 2.5-5 mg every 4 hr or 7.5 mg every 6-8 hr; up to 2 yr: Individualised dosage. Extended release oral suspension: 6-12 yr: 30 mg bid; 2-6 yr: 15 mg bid. Max: 6-12 yr: 60 mg/day; 2-6 yr: 30 mg/day.
Contraindications
 Patients at risk of developing resp failure. During an acute attack. Patients receiving MAOI or for 2 wk after discontinuing them. Persistent or chronic cough.
Warnings / Precautions
 3rd trimester of pregnancy; atopic childn; child <1 yr; sedated or debilitated patients; patients confined to supine position; history of asthma. Moderate to severe renal impairment; liver disease.
Adverse Reactions
 Dizziness, GI disturbances.
Overdose Reactions
 Symptoms: In mild overdose, tachycardia, hypertension, vomiting, mydriasis, diaphoresis, nystagmus, euphoria, loss of motor coordination, and giggling; in moderate intoxication, in addition to those listed above, hallucinations and a plodding ataxic gait; in severely intoxication, agitation or somnolence. Management: treatment is symptomatic and supportive. Naloxone may be useful in reversing toxicity.
Drug Interactions
 Tricyclic antidepressants (TCAs), antipsychotics, anxiolytics and hypnotics, cimetidine, ciprofloxacin, domperidone, metoclopramide, mexiletine, CYP2D6 inhibitors, ritonavir, alcohol.
Potentially Fatal: Memantine, moclobemide.
See Below for More dextromethorphan Drug Interactions
Mechanism of Actions
 Dextromethorphan, a derivative of levorphanol, is an antitussive agent. It has a central action on the cough center in the medulla.
Onset: Oral: 30 minutes.
Duration: Oral: Up to 6 hr.
Absorption: Rapidly absorbed in the GI tract.
Metabolism: Hepatically metabolised.
Excretion: Excreted in the urine unchanged.
Administration
 May be taken with or without food.
Storage Conditions
 Oral: Store at 15-30°C.
ATC Classification
 R05DA09 - dextromethorphan ; Belongs to the class of opium alkaloids and derivatives. Used as cough suppressant.
Storage
 Oral: Store at 15-30°C.
Available As
  • Dextromethorphan Hydrobromide 10 mg
  • Dextromethorphan 10 mg
  • Dextromethorphan Hydrobromide 100 mg
  • Dextromethorphan Hydrobromide 15 mg
  • Dextromethorphan 15 mg
  • Dextromethorphan Hydrobromide 20 mg
  • Dextromethorphan 20 mg
  • Dextromethorphan 30 mg
  • Dextromethorphan 32 mg
  • Dextromethorphan Hydrobromide 32.5 mg
  • Dextromethorphan Hydrobromide 4 mg
  • Dextromethorphan Hydrobromide 5 mg
  • Dextromethorphan 5 mg
  • Dextromethorphan Hydrobromide 50 mg
  • Dextromethorphan 6.5 mg
  • Dextromethorphan Hydrobromide 7.5 mg
  • Dextromethorphan 7.5 mg

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