Desloratadine

Indications
 Oral
Allergic conditions
Adult: 5 mg once daily.
Child: ≥12 yr: 5 mg once daily; 6-11 yr: 2.5 mg; 1-5 yr: 1.25 mg; 6-11 mth: 1 mg. Doses to be taken once daily.
Renal impairment: Initially, 5 mg every other day.
Hepatic impairment: Initially, 5 mg every other day.
Contraindications
 Hypersensitivity.
Warnings / Precautions
 Severe renal or hepatic failure; children <6 mth, elderly, epilepsy, pregnancy and lactation.
Adverse Reactions
 Headache, fatigue, somnolence, dizziness; nausea, dyspepsia; xerostomia, dysmenorrhoea; pharyngitis.
Overdose Reactions
 Treatment is symptomatic and supportive. Standard measures to reduce absorption to be adopted. Haemodialysis unlikely to be useful.
Mechanism of Actions
 Desloratadine is a long-acting, tricyclic, non-sedating, selective peripheral histamine H1-receptor antagonist which inhibits the release of pro-inflammatory mediators from human mast cells and basophils.
Absorption: Peak plasma concentrations after 3 hr (oral).
Distribution: Protein-binding: 82-87%.
Metabolism: Hepatic; converted to 3-hydroxydesloratadine.
Excretion: Via urine and faeces (as metabolites).
Administration
 May be taken with or without food.
Storage Conditions
 Oral: Store below 30°C.
ATC Classification
 R06AX27 - desloratadine ; Belongs to the class of other antihistamines for systemic use.
Storage
 Oral: Store below 30°C.
Available As
  • Desloratadine 2.5 mg
  • Desloratadine 5 mg

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