Clotrimazole

Indications
 Oral
Oropharyngeal candidiasis
Adult: Per lozenge contains 10 mg clotrimazole: Suck 1 lozenge 5 times daily for 14 days. For prevention in patients receiving immunosuppressant therapy: 1 lozenge tid for the immunosuppressant treatment duration.
Otic/Aural
Fungal otitis externa
Adult: Apply 1% solution to affected area.
Topical/Cutaneous
Skin fungal infections
Adult: Apply a 1% cream/lotion/solution bid-tid for 2-4 wk, may be used with a 1% powder to prevent reinfection.
Vaginal
Vulvovaginal candidiasis
Adult: As pessary: 100 mg daily for 6 days, 200 mg daily for 3 days or 500 mg as a single dose; alternatively, apply 1, 2 or 10% cream.
Contraindications
 Hypersensitivity.
Warnings / Precautions
 Avoid contact with eyes upon topical application. Childn <3 yrs. Pregnancy, lactation.
Adverse Reactions
 Topical: Erythema, stinging, irritation; hypersensitivity reactions; contact dermatitis. Oral: GI disturbances, dysuria, mental depression, elevated liver enzymes.
Drug Interactions
 Antagonism with polyene antibiotics.
See Below for More clotrimazole Drug Interactions
Mechanism of Actions
 Clotrimazole is a broad-spectrum antifungal which binds to phospholipids in the cell membrane altering cell wall permeability causing a loss in essential intracellular elements.
Absorption: Negligible through intact skin (topical); 3-10% (vaginal).
Metabolism: Hepatic; converted to inactive metabolites.
Excretion: Urine, faeces (as metabolites).
Storage Conditions
 Oral: Store below 30°C. Otic/Aural: Store below 30°C. Topical/Cutaneous: Store below 30°C. Vaginal: Store below 30°C.
ATC Classification
 D01AC01 - clotrimazole ; Belongs to the class of imidazole and triazole derivatives. Used in the topical treatment of fungal infection.
G01AF02 - clotrimazole ; Belongs to the class of imidazole derivative antiinfectives. Used in the treatment of gynecological infections.
A01AB18 - clotrimazole ; Belongs to the class of local antiinfective and antiseptic preparations. Used in the treatment of diseases of the mouth.
Storage
 Oral: Store below 30°C. Otic/Aural: Store below 30°C. Topical/Cutaneous: Store below 30°C. Vaginal: Store below 30°C.
Available As
  • Clotrimazole IP 0.50% w/w
  • Clotrimazole 1 mg
  • Clotrimazole 1%
  • Clotrimazole IP 1% w/v
  • Clotrimazole 1% w/v
  • Clotrimazole 1% w/w
  • Clotrimazole IP 1% w/w
  • Clotrimazole 1.0 w/w
  • Clotrimazole 1.0%
  • Clotrimazole IP 1.0% w/v
  • Clotrimazole 1.0% w/v
  • Clotrimazole 1.0% w/w
  • Clotrimazole 1.00%
  • Clotrimazole 1.000% w/w
  • Clotrimazole IP 1.000% w/w
  • Clotrimazole 10 gm
  • Clotrimazole 10 mg
  • Clotrimazole 100 mg
  • Clotrimazole 150 mg
  • Clotrimazole 2%
  • Clotrimazole 2% w/v
  • Clotrimazole 2% w/w
  • Clotrimazole 20 mg
  • Clotrimazole 200 mg
  • Clotrimazole 250 mg
  • Clotrimazole 500 mg

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