Cefpirome

Indications
 Intravenous
Susceptible infections
Adult: As sulfate: 1-2 g every 12 hr via IV inj over 3-5 minutes or infuse over 20-30 minutes.
Renal impairment: Loading dose: 1-2 g followed by a maintenance dose adjusted according to CrCl.
CrCl (ml/min)Dosage Recommendation
20-500.5-1 g bid.
5-200.5-1 g once daily.
<5 (in haemodialysis patients)0.5 or 1 g once daily with half-dose after each dialysis session.


Special Populations: Renal impairment: 1-2 g loading dose followed by a maintenance dose adjusted according to CrCl: 20-50 mL/min: 0.5-1 g bid; 5-20 mL/min: 0.5-1 g once daily; ≤5 mL/min (patients on haemodialysis): 0.5-1 g once daily including ½ after each dialysis.
Contraindications
 Hypersensitivity; porphyria.
Warnings / Precautions
 Allergy to penicillin or to cephalosporins; renal impairment, monitor renal and haematological status; pregnancy and lactation.
Adverse Reactions
 Rash, pruritus, urticaria; nausea, vomiting, abdominal pain, diarrhoea; increased plasma levels of ASAT, ALAT, gamma-GT, LDH, bilirubin and/or alkaline phosphatase; interstitial nephritis, acute renal failure; thrombocytopaenia, eosinophilia, haemolytic anaemia, neutropaenia, agranulocytosis; thrombophloebitis, pain at Inj site; convulsions, fever; haemorrhage.
Potentially Fatal: Pseudomembranous colitis.
Drug Interactions
 Reduced clearance with probenecid.
See Below for More cefpirome Drug Interactions
Lab Interactions
 Interferes with Jaffe method of creatinine conc measurement in determining renal function.
Mechanism of Actions
 Cefpirome binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Distribution: Widely distributed into body tissues and fluids; enters breast milk. Protein-binding: 10%
Excretion: Mainly by the kidneys via the urine (80-90% as unchanged); significantly removed by haemodialysis; 2 hrs (elimination half-life); prolonged in renal impairment.
Storage Conditions
 Intravenous: Store below 25°C.
ATC Classification
 J01DE02 - cefpirome ; Belongs to the class of fourth generation cephalosporins. Used in the systemic treatment of infections.
Storage
 Intravenous: Store below 25°C.
Available As
  • Cefpirome 1000 mg
  • Cefpirome 125 mg
  • Cefpirome 2000 mg
  • Cefpirome 250 mg
  • Cefpirome 500 mg

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